An inhibitor of class I (IC50s = 0.1

MC1742 – 10 mg

Brand:
Cayman
CAS:
1776116-74-5
Storage:
-20
UN-No:
Non-Hazardous - /

MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).{48634} It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin and induces apoptosis in MG-63 CSCs when used at a concentration of 2 μM. MC1742 also reactivates HIV-1 in JLAT 10.6 latently infected cells (EC50 = 350 nM).{48635}  

 

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SKU: 29171 - 10 mg Category:

Description

An inhibitor of class I (IC50s = 0.1, 0.11, 0.02, 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively); selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9); reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma CSCs; increases levels of acetylated histone H3 and acetylated tubulin and induces apoptosis in MG-63 CSCs at 2 μM; reactivates HIV-1 in JLAT 10.6 latently-infected cells (EC50 = 350 nM)

Formal name: 5-[(4-[1,1′-biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxy-pentanamide

Synonyms: 

Molecular weight: 395.5

CAS: 1776116-74-5

Purity: ≥98%

Formulation: A solid

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