A diterpenoid with diverse biological activities; inhibits IL-2 production and DNA synthesis in phytohemagglutinin-stimulated T cells (EC50s = 2.46 and 3.2 ng/ml

(−)-Triptonide – 50 mg

Brand:
Cayman
CAS:
38647-11-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

(–)-Triptonide is a diterpenoid that has been found in T. wilfordii and has diverse biological activities, including immunosuppressant and anticancer properties.{52152,52153} It inhibits IL-2 production and DNA synthesis in phytohemagglutinin-stimulated T cells (EC50s = 2.46 and 3.2 ng/ml, respectively).{52152} (–)-Triptonide inhibits the proliferation of PC3, DU145, and LNCaP cells (IC50s = 11.96, 10.26, 12.01 nM, respectively).{52153} It induces cell cycle arrest at the G2/M phase and increases apoptosis in PC3 cells in a concentration-dependent manner. (–)-Triptonide (10 mg/kg per day) reduces tumor growth in a PC3 mouse xenograft model.  

 

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Description

A diterpenoid with diverse biological activities; inhibits IL-2 production and DNA synthesis in phytohemagglutinin-stimulated T cells (EC50s = 2.46 and 3.2 ng/ml, respectively); inhibits the proliferation of PC3, DU145, and LNCaP cells (IC50s = 11.96, 10.26, 12.01 nM, respectively); induces cell cycle arrest at the G2/M phase and increases apoptosis in PC3 cells in a concentration-dependent manner; reduces tumor growth in a PC3 mouse xenograft model at 10 mg/kg per day

Formal name: (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione

Synonyms:  NSC 165677|Triptonide

Molecular weight: 358.4

CAS: 38647-11-9

Purity: ≥98%

Formulation: A crystalline solid

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