A fungal metabolite with diverse biological activities; active against isolates of B. cinerea

Cyclosporin C – 1 mg

Brand:
Cayman
CAS:
59787-61-0
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties.{24990,53111,53112,53113} It is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs = 0.1-5 μg/ml).{53111} Cyclosporin C (15 μg/ml) inhibits vaccinia virus replication in infected BSC40 cells by 98.82%.{53112} It inhibits lymphocyte proliferation induced by the mitogens concanavalin A (ConA; Item No. 14951), phytohemagglutinin L (PHA), and pokeweed mitogen (PWM), as well as proliferation induced by alloantigen in mixed lymphocyte culture when used at a concentration of 100 ng/ml.{53113} Cyclosporin C (100 ng/ml) inhibits the local graft versus host (GVH) reaction in mice receiving splenocyte grafts.  

 

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SKU: 29152 - 1 mg Category:

Description

A fungal metabolite with diverse biological activities; active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs = 0.1-5 μg/ml); inhibits vaccinia virus replication in infected BSC40 cells by 98.82% at 15 μg/ml; inhibits lymphocyte proliferation induced by the mitogens ConA, PHA, and PWM, as well as proliferation induced by alloantigen in mixed lymphocyte at 100 ng/ml; inhibits the local GVH reaction in mice receiving splenocyte grafts at 100 ng/ml

Formal name: 7-L-threonine-cyclosporin A

Synonyms: 

Molecular weight: 1,218.60

CAS: 59787-61-0

Purity: ≥95%

Formulation: A crystalline solid

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