A polyphenol flavonoid dimer with diverse biological activities; inhibits Aβ42 aggregation (IC50 = 3.54 μM); destabilizes preformed Aβ42 fibrils (EC50 = 5.12 μM); reduces oxidation of linoleic acid and scavenges DPPH free radicals in cell free assays at 1 mM; inhibits hydrogen peroxide-induced production of iNOS and apoptosis in primary murine chondrocytes; reduces chondrocyte apoptosis

Procyanidin B3 – 5 mg

Brand:
Cayman
CAS:
23567-23-9
Storage:
-20
UN-No:
Non-Hazardous - /

Procyanidin B3 is a polyphenol flavonoid dimer of (+)-catechin (Item No. 70940) that has been found in G. biloba and has diverse biological activities.{27617,52199,52200} It inhibits aggregation of amyloid-β (1-42) (Aβ42; Item No. 20574) with an IC50 value of 3.54 μM and destabilizes preformed Aβ42 fibrils (EC50 = 5.12 μM).{27617} Procyanidin B3 (1 mM) reduces oxidation of linoleic acid and scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in cell-free assays.{52199} It inhibits hydrogen peroxide-induced production of inducible nitric oxide synthase (iNOS) and apoptosis in primary murine chondrocytes.{52200} Procyanidin B3 (0.01 mg/kg) reduces chondrocyte apoptosis, pseudocapsule thickness, and the frequency of ectopic cartilage formation in a mouse model of surgically induced osteoarthritis.  

 

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Description

A polyphenol flavonoid dimer with diverse biological activities; inhibits Aβ42 aggregation (IC50 = 3.54 μM); destabilizes preformed Aβ42 fibrils (EC50 = 5.12 μM); reduces oxidation of linoleic acid and scavenges DPPH free radicals in cell free assays at 1 mM; inhibits hydrogen peroxide-induced production of iNOS and apoptosis in primary murine chondrocytes; reduces chondrocyte apoptosis, pseudocapsule thickness, and the frequency of ectopic cartilage formation in a mouse model of surgically induced osteoarthritis at 0.01 mg/kg

Formal name: (2R,2′R,3S,3′S,4S)-2,2′-bis(3,4-dihydroxyphenyl)-3,3′,4,4′-tetrahydro-[4,8′-bi-2H-1-benzopyran]-3,3′,5,5′,7,7′-hexol

Synonyms:  Proanthocyanidin B3|Procyanidol B3

Molecular weight: 578.5

CAS: 23567-23-9

Purity: ≥98%

Formulation: A crystalline solid

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