Mirodenafil (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
862189-96-6
Storage:
-20
UN-No:
Non-Hazardous - /

Mirodenafil is a phosphodiesterase 5 (PDE5) inhibitor.{53073} It increases penile intracavernosal pressure (ICP) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) and in a rat model of cavernosal nerve injury when administered at doses of 1 and 10 mg/kg, respectively.{53073,53074} Mirodenafil (4 mg/kg per day) decreases bladder wall submucosal fibrosis and degeneration in a rat model of chronic bladder ischemia.{53075} It also decreases bladder overactivity in a female rat model of partial bladder outlet obstruction.{53076}  

 

Available on backorder

SKU: 29045 - 1 mg Category:

Description

A PDE5 inhibitor; increases penile ICP in rat models of STZ-induced diabetes and cavernosal nerve injury at 1 and 10 mg/kg, respectively; decreases bladder wall submucosal fibrosis and degeneration in a rat model of chronic bladder ischemia at 4 mg/kg per day; decreases bladder overactivity in a female rat model of partial bladder outlet obstruction


Formal name: 5-ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one, dihydrochloride

Synonyms:  SK3530

Molecular weight: 604.6

CAS: 862189-96-6

Purity: ≥95%

Formulation: A crystalline solid