A prodrug form of valdecoxib; converted to valdecoxib by human liver microsomes in vitro and in vivo in rats

Parecoxib (sodium salt) – 50 mg

Brand:
Cayman
CAS:
198470-85-8
Storage:
-20
UN-No:
Non-Hazardous - /

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib (Item No. 10006120).{47736} It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 µM in HEK293 cells.{47737} It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).{47736}  

 

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SKU: 29017 - 50 mg Category:

Description

A prodrug form of valdecoxib; converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys; a CB1 agonist (EC50 = 2.4 µM in HEK293 cells); reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg)

Formal name: N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-propanamide, monosodium salt

Synonyms:  SC-69124A

Molecular weight: 392.4

CAS: 198470-85-8

Purity: ≥98%

Formulation: A solid

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