An inhibitor of the Hec1-Nek2 interaction; binds to Hec1 and reduces Nek2 protein levels in HeLa cells at 25 µM; inhibits the growth of various breast cancer cells (GI50s = 10.5-20.5 µM); inhibits migration of MDA-MB-231 cells in a transwell migration assay (IC50 = 176 nM); reduces tumor growth in an MDA-MB-468 mouse xenograft model at 50 and 100 mg/kg

INH1 – 5 mg

Brand:
Cayman
CAS:
313553-47-8
Storage:
-20
UN-No:
Non-Hazardous - /

INH1 is an inhibitor of the interaction between the oncogene high expression in cancer 1 (Hec1) and its regulator, the serine/threonine kinase Nek2.{48794} It binds to Hec1 and reduces Nek2 protein levels in HeLa cells when used at a concentration of 25 µM. INH1 inhibits the growth of MDA-MB-468, SK-BR-3, T47D, MDA-MB-361, ZR-75-1, HBL-100, MDA-MB-435, and Hs 578T breast cancer cells (GI50s = 10.5-20.5 µM). It inhibits migration of MDA-MB-231 cells in a transwell migration assay (IC50 = 176 nM).{48795} INH1 (50 and 100 mg/kg) reduces tumor growth in an MDA-MB-468 mouse xenograft model.{48794}  

 

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Description

An inhibitor of the Hec1-Nek2 interaction; binds to Hec1 and reduces Nek2 protein levels in HeLa cells at 25 µM; inhibits the growth of various breast cancer cells (GI50s = 10.5-20.5 µM); inhibits migration of MDA-MB-231 cells in a transwell migration assay (IC50 = 176 nM); reduces tumor growth in an MDA-MB-468 mouse xenograft model at 50 and 100 mg/kg

Formal name: N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-benzamide

Synonyms:  IBT 13131

Molecular weight: 308.4

CAS: 313553-47-8

Purity: ≥98%

Formulation: A crystalline solid

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