A prodrug form of cytarabine; hydrolyzed to cytarabine in vivo; inhibits the growth of L5178Y leukemia cells in vitro (IC50 = 0.041 µg/ml); inhibits DNA synthesis by inhibiting thymidine incorporation into DNA (IC50 = 110 µg/ml); increases lifespan in an L1210 mouse leukemia model at 3-1

Cyclocytidine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
10212-25-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclocytidine is a prodrug form of cytarabine (Item No. 16069) that is hydrolyzed to cytarabine in vivo.{45623} It inhibits the growth of L5178Y leukemia cells in vitro (IC50 = 0.041 µg/ml) and inhibits DNA synthesis by inhibiting thymidine incorporation into DNA (IC50 = 110 µg/ml).{45624} It increases lifespan in an L1210 mouse model of leukemia when administered at doses ranging from 3 to 1,000 mg/kg per day.{45623} Cyclocytidine transiently increases blood pressure in dogs, cats, and rats when administered at doses ranging from 5 to 100 mg/kg and induces postural hypotension in dogs, an effect that can be blocked by the α-adrenergic receptor antagonist phentolamine (Item No. 16135).{45625}  

 

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SKU: 29014 - 1 g Category:

Description

A prodrug form of cytarabine; hydrolyzed to cytarabine in vivo; inhibits the growth of L5178Y leukemia cells in vitro (IC50 = 0.041 µg/ml); inhibits DNA synthesis by inhibiting thymidine incorporation into DNA (IC50 = 110 µg/ml); increases lifespan in an L1210 mouse leukemia model at 3-1,000 mg/kg per day; transiently increases blood pressure in dogs, cats, and rats at 5-100 mg/kg

Formal name: (2R,3R,3aS,9aR)-tetrahydro-3-hydroxy-6-imino-6H-furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol, monohydrochloride

Synonyms:  2,2′-O-Cyclocytidine hydrochloride|Ancitabine hydrochloride|NSC 145668

Molecular weight: 261.7

CAS: 10212-25-6

Purity: ≥95%

Formulation: A crystalline solid

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