An inhibitor of Mer kinase (IC50 = 4.3 nM); selective for Mer over Axl and TYRO3 (IC50s = 360 and 250 nM

UNC2881 – 5 mg

Brand:
Cayman
CAS:
1493764-08-1
Storage:
-20
UN-No:
Non-Hazardous - /

UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases.{45606} It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.  

 

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SKU: 29012 - 5 mg Category:

Description

An inhibitor of Mer kinase (IC50 = 4.3 nM); selective for Mer over Axl and TYRO3 (IC50s = 360 and 250 nM, respectively); inhibits phosphorylation of Mer in 697 B-ALL cells (IC50 = 21.9 nM); inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma at 3 μM

Formal name: 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide

Synonyms: 

Molecular weight: 463.6

CAS: 1493764-08-1

Purity: ≥98%

Formulation: A crystalline solid

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