Ginsenoside Rb3 – 50 mg

Brand:
Cayman
CAS:
68406-26-8
Storage:
-20
UN-No:
Non-Hazardous - /

Ginsenoside Rb3 is a steroid glycoside that has been found in Panax and has diverse biological activities.{46577,46578,46579,46580,46581} It inhibits JNK-mediated activation of NF-κB and apoptosis induced by oxygen-glucose deprivation (OGD) in H9c2 mouse cardiac myoblasts in vitro and reduces myocardial apoptosis and production of reactive oxygen species (ROS) in a rat model of myocardial ischemia-reperfusion injury when administered at a dose of 20 mg/kg.{46577,46578} Ginsenoside Rb3 (10 and 20 mg/kg per day for 10 days) prevents increases in serum creatinine, blood urea nitrogen (BUN), and malondialdehyde (MDA) levels, and decreases in superoxide dismutase (SOD) activity and glutathione (GSH) levels, as well as inhibits renal cell apoptosis in a mouse model of nephrotoxicity induced by cisplatin (Item No. 13119).{46579} It decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer.{46580} Ginsenoside Rb3 also decreases immobility time in the forced swim and tail suspension tests, indicating antidepressant-like activity, in mice.{46581}  

 

Available on backorder

SKU: 29005 - 50 mg Category:

Description

A steroid glycoside with diverse biological activities; inhibits OGD-induced JNK-mediated activation of NF-κB and apoptosis in H9c2 mouse cardiac myoblasts; reduces myocardial apoptosis and production of ROS in a rat model of myocardial ischemia-reperfusion injury at 20 mg/kg; prevents increases in serum creatinine, BUN, MDA, and decreases in SOD activity and GSH levels, as well as inhibits renal cell apoptosis in a mouse model of cisplatin-induced nephrotoxicity at 10 and 20 mg/kg; decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer; decreases immobility time in the forced swim and tail suspension tests in mice


Formal name: (3β,12β)-3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside

Synonyms:  Ginsenoside IV

Molecular weight: 1,079.30

CAS: 68406-26-8

Purity: ≥98%

Formulation: A solid