A synthetic non-steroidal estrogen that binds to ERα and ERβ (Kis = 0.06 and 0.06 nM for the human and rat receptors

Hexestrol – 500 mg

Brand:
Cayman
CAS:
84-16-2
Storage:
-20
UN-No:
Non-Hazardous - /

Hexestrol is a synthetic non-steroidal estrogen receptor ligand that binds to estrogen receptor α (ERα) and ERβ (Kis = 0.06 and 0.06 nM for the human and rat receptors, respectively).{23592} It inhibits rat liver microsomal and ox brain phospholipid liposomal lipid peroxidation (IC50s = 1.5 and 2.75 μM, respectively).{45569} It also inhibits porcine microtubule assembly and induces disassembly of preformed microtubules when used at concentrations of 50 and 100 μM, respectively, in a cell-free assay.{45571} Hexestrol (25 mg/animal) induces kidney tumors in male Syrian hamsters.{45570}  

 

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SKU: 29003 - 500 mg Category:

Description

A synthetic non-steroidal estrogen that binds to ERα and ERβ (Kis = 0.06 and 0.06 nM for the human and rat receptors, respectively); inhibits rat liver microsomal and ox brain phospholipid liposomal lipid peroxidation (IC50s = 1.5 and 2.75 μM, respectively); inhibits porcine microtubule assembly and induces disassembly of preformed microtubules at 50 and 100 μM, respectively, in a cell-free assay; induces kidney tumors in male Syrian hamsters at 25 mg/animal

Formal name: rel-4,4′-[(1R,2S)-1,2-diethyl-1,2-ethanediyl]bis-phenol

Synonyms:  meso-Hexestrol|Hexoestrol|NSC 9894

Molecular weight: 270.4

CAS: 84-16-2

Purity: ≥98%

Formulation: A crystalline solid

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