A DNA topoisomerase I inhibitor; inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay; inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM

Rubitecan – 50 mg

Brand:
Cayman
CAS:
91421-42-0
Storage:
-20
UN-No:
Non-Hazardous - /

Rubitecan is a DNA topoisomerase I inhibitor.{53039,53040} It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.{53039} Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively).{53041} It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.{53042}  

 

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SKU: 28956 - 50 mg Category:

Description

A DNA topoisomerase I inhibitor; inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay; inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively); inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively); reduces tumor growth in a U937 leukemia mouse xenograft model at 4 mg/kg twice per week

Formal name: (4S)-ethyl-4-hydroxy-10-nitro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Synonyms:  9-nitro-20(S)-Camptothecin|RFS 2000

Molecular weight: 393.4

CAS: 91421-42-0

Purity: ≥98%

Formulation: A crystalline solid

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