An endogenous N-acyl amine; induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64% at 50 µM; inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with TRPV1 and RFP; reduces the number of acetic acid-induced abdominal constrictions

N-Oleoyl Glutamine – 10 mg

Brand:
Cayman
CAS:
247150-73-8
Storage:
-20
UN-No:
Non-Hazardous - /

N-Oleoyl glutamine is an endogenous N-acyl amine.{31656,49699} It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 µM) induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64%.{49700} It inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with transient receptor potential vanilloid 1 (TRPV1) and red fluorescent protein (RFP).{49699} N-Oleoyl glutamine (100 mg/kg) reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice.  

 

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Description

An endogenous N-acyl amine; induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64% at 50 µM; inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with TRPV1 and RFP; reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice at 100 mg/kg

Formal name: N2-[(9Z)-1-oxo-9-octadecen-1-yl]-L-glutamine

Synonyms: 

Molecular weight: 410.6

CAS: 247150-73-8

Purity: ≥95%

Formulation: A crystalline solid

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