An inhibitor of PARP10 (IC50 = 329 nM); selective for PARP10 over a panel of 15 PARP enzymes

OUL35 – 10 mg

Brand:
Cayman
CAS:
6336-34-1
Storage:
-20
UN-No:
Non-Hazardous - /

OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10; IC50 = 329 nM).{45541} It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively). OUL35 (10 μM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea (Item No. 23725), increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 μM.  

 

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Description

An inhibitor of PARP10 (IC50 = 329 nM); selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively); reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression at 10 μM; sensitizes HeLa cells to hydroxyurea, increasing hydroxyurea-induced inhibition of cell proliferation at 5 μM

Formal name: 4,4′-oxybis-benzamide

Synonyms:  NSC 39047

Molecular weight: 256.3

CAS: 6336-34-1

Purity: ≥95%

Formulation: A crystalline solid

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