A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction

Panaxatriol – 25 mg

Brand:
Cayman
CAS:
32791-84-7
Storage:
-20
UN-No:
Non-Hazardous - /

Panaxatriol is a sapogenin that has been found in P. ginseng and has diverse biological activities, including antiproliferative, cardioprotective, and antidiabetic properties.{52069,52070,52071} It inhibits the proliferation of DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of reactive oxygen species (ROS) and decreasing the mitochondrial membrane potential.{52069} Panaxatriol (5 mg/kg) reduces ischemia and reperfusion-induced myocardial dysfunction, increases left ventricular developed pressure (LVDevP) and glutathione (GSH) levels, and decreases cardiac lactate dehydrogenase (LDH), creatine kinase (CK), and malondialdehyde (MDA) levels in rats when administered for seven consecutive days prior to injury.{52070} Dietary administration of panaxatriol (0.2% for 6 weeks) decreases fasting blood glucose levels in KKAy insulin-resistant mice.{52071}  

 

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SKU: 28835 - 25 mg Category:

Description

A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction, increases LVDevP and GSH levels, and decreases cardiac LDH, CK, and MDA levels in isolated rats at 5 mg/kg for seven consecutive days prior to injury; decreases fasting blood glucose levels in KKAy insulin-resistant mice at 0.2% in chow for 6 weeks

Formal name: (3β,6β,12β,20R)-20,25-epoxy-dammarane-3,6,12-triol

Synonyms:  NSC 308880

Molecular weight: 476.7

CAS: 32791-84-7

Purity: ≥95%

Formulation: A solid

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