Rose Bengal (sodium salt) – 25 g

Brand:
Cayman
CAS:
632-69-9
Storage:
-20
UN-No:
Non-Hazardous - /

Rose bengal is a xanthene dye, fluorescein derivative, and photosensitizer.{46508,46509} It exhibits absorption/emission maxima of 548/567 nm, respectively.{22804} Rose bengal binds to S. aureus cells and decreases survival of photoirradiated S. aureus to 0.012% when used at a concentration of 1 μM.{46508} It generates singlet oxygen when exposed to photoirradiation in cell-free assays and induces potassium ion leakage from S. aureus and bovine erythrocytes in the presence of photoirradiation. Rose bengal inhibits the cytochrome P450 (CYP) isoform CYP3A4/5 and the UDP-glucuronosyltransferase (UGT) isoform UGT1A6 in human liver microsomes in a light-dependent manner, with IC50 values of 0.072 and 0.035 μM, respectively, in yellow light, 3.1 and 4.2 μM, respectively, in ambient light, and 3 and 4.2 μM, respectively, in the dark.{46510} It has been used for staining of live cells, but exhibits both intrinsic and phototoxicity.{46509}  

 

Available on backorder

SKU: 28829 - 25 g Category:

Description

A xanthene dye, fluorescein derivative, and photosensitizer; abs/em maxima = 548/567 nm, respectively; binds to S. aureus cells and decreases survival of photoirradiated S. aureus to 0.012% at 1 μM; generates singlet oxygen when exposed to photoirradiation in cell-free assays; induces potassium ion leakage from S. aureus and bovine erythrocytes in the presence of photoirradiation; inhibits CYP3A4/5 and UGT1A6 in human liver microsomes in a light-dependent manner (IC50s = 0.072 and 0.035 μM, respectively, in yellow light, 3.1 and 4.2 μM, respectively, in ambient light, and 3 and 4.2 μM, respectively, in the dark); has been used for staining of live cells, but exhibits both intrinsic and phototoxicity


Formal name: 4,5,6,7-tetrachloro-3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodo-spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one, disodium salt

Synonyms:  Acid Red 94|Japan Red 105-1|Red No. 105-1

Molecular weight: 1,017.60

CAS: 632-69-9

Purity: ≥90%

Formulation: A crystalline solid