A sulfonamide antibiotic; inhibits recombinant P. carinii DHPS (IC50 = 25 nM) in a cell-free assay; active against S. aureus

Sulfadimethoxine – 10 g

Brand:
Cayman
CAS:
122-11-2
Storage:
-20
UN-No:
Non-Hazardous - /

Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms.{47622} It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay.{38582} Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay.{47622} It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml).{46521,46522} Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).{47622}  

 

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Description

A sulfonamide antibiotic; inhibits recombinant P. carinii DHPS (IC50 = 25 nM) in a cell-free assay; active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay; active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml); efficacious S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice (CD50s = 79.7, 2.7, and 12.2 mg/kg, respectively); efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg)

Formal name: 4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamide

Synonyms:  Sulphadimethoxine

Molecular weight: 310.3

CAS: 122-11-2

Purity: ≥98%

Formulation: A solid

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