A triterpenoid sapogenin; inhibits IL-1β and ROS production from LPS-induced mouse BV2 microglia at 4 μM; decreases NLRP3 inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced mouse model of Parkinson’s disease at 25 mg/kg per day; reduces increases in lung edema and BALF IL-1β and TNF-α levels in a mouse model of intranasal S. aureus-induced pneumonia at 2 mg/kg

Tenuigenin – 5 mg

Brand:
Cayman
CAS:
2469-34-3
Storage:
-20
UN-No:
Non-Hazardous - /

Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties.{48609,48607,48608} It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM.{48607} Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson’s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.{48608}  

 

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Description

A triterpenoid sapogenin; inhibits IL-1β and ROS production from LPS-induced mouse BV2 microglia at 4 μM; decreases NLRP3 inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced mouse model of Parkinson’s disease at 25 mg/kg per day; reduces increases in lung edema and BALF IL-1β and TNF-α levels in a mouse model of intranasal S. aureus-induced pneumonia at 2 mg/kg

Formal name: (2β,3β,4α,12α)-12-(chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid

Synonyms:  Senegenin

Molecular weight: 537.1

CAS: 2469-34-3

Purity: ≥98%

Formulation: A crystalline solid

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