A broad-spectrum β-lactam antibiotic; active against aerobic and anaerobic

Biapenem – 25 mg

Brand:
Cayman
CAS:
120410-24-4
Storage:
-20
UN-No:
Non-Hazardous - /

Biapenem is a broad-spectrum β-lactam antibiotic.{47703,47704} It is active against aerobic and anaerobic, Gram-positive and Gram-negative bacteria, including clinical isolates of E. coli, oxacillin-sensitive S. aureus, B. fragilis, and Clostridium (MIC90s = 0.12, 0.12, 0.25, and 1 μg/ml, respectively). It is also active against the rifampicin-susceptible H37Rv and rifampicin-resistant 115R and 124R M. tuberculosis strains (MICs = 2-4, 4-8, and 8-16 mg/L, respectively).{47705} Biapenem (200 mg/kg) decreases the number of lung colony-forming units (CFUs) in a mouse model of late-phase acute H37Rv M. tuberculosis infection.  

 

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SKU: 28822 - 25 mg Category:

Description

A broad-spectrum β-lactam antibiotic; active against aerobic and anaerobic, Gram-positive and Gram-negative bacteria, including clinical isolates of E. coli, oxacillin-sensitive S. aureus, B. fragilis, and Clostridium (MIC90s = 0.12, 0.12, 0.25, and 1 μg/ml, respectively); active against the rifampicin-susceptible H37Rv and rifampicin-resistant 115R and 124R M. tuberculosis strains (MICs = 2-4, 4-8, and 8-16 mg/L, respectively); decreases the number of lung CFUs in a mouse model of M. tuberculosis infection at 200 mg/kg

Formal name: 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium, inner salt

Synonyms:  CL 186815|LJC 10,627

Molecular weight: 350.4

CAS: 120410-24-4

Purity: ≥95%

Formulation: A crystalline solid

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