A bacterial metabolite; scavenges ABTS radicals in a cell-free assay at 50-150 µM and decreases hydrogen peroxide-induced MDA levels in rat striatal membranes (IC50 = 180 µM); decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells; decreases ischemia-induced increases in cell death of pyramidal neurons and levels of HNE and GFAP in the hippocampal CA1 region in gerbils at 10 mg/kg per day

Indole-3-propionic Acid – 100 g

Brand:
Cayman
CAS:
830-96-6
Storage:
-20
UN-No:
Non-Hazardous - /

Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities.{53033,53034,53035} It scavenges ABTS (Item No. 27317) radicals in a cell-free assay when used at concentrations ranging from 50 to 150 µM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 µM).{53034} Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) (Item No. 20574) in PC12 cells.{53036} It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; Item No. 32100) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.{53035}  

 

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SKU: 28821 - 100 g Category:

Description

A bacterial metabolite; scavenges ABTS radicals in a cell-free assay at 50-150 µM and decreases hydrogen peroxide-induced MDA levels in rat striatal membranes (IC50 = 180 µM); decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells; decreases ischemia-induced increases in cell death of pyramidal neurons and levels of HNE and GFAP in the hippocampal CA1 region in gerbils at 10 mg/kg per day

Formal name: 1H-indole-3-propanoic acid

Synonyms:  3-Indolepropionic Acid|NSC 3252|NSC 47831

Molecular weight: 189.2

CAS: 830-96-6

Purity: ≥98%

Formulation: A crystalline solid

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