Description
A partial agonist of the 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay); increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors); decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats at 0.032 mg/kg
Formal name: tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-2H-pyran-4-ol
Synonyms:
Molecular weight: 432.5
CAS: 1331782-27-4
Purity: ≥98%
Formulation: A crystalline solid
