An orally bioavailable

Carboxyamidotriazole – 5 mg

Brand:
Cayman
CAS:
99519-84-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Carboxyamidotriazole is an orally bioavailable, non-selective calcium channel blocker.{45500} It blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 μg/ml, respectively). It also inhibits calcium influx stimulated by the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) and the calcium ionophore A23187 (Item Nos. 11016 | 22030) in CHO cells expressing human recombinant muscarinic M5 receptors (IC50s = 935 and 359 nM, respectively).{45501} Carboxyamidotriazole inhibits the growth of T. gondii in non-cancerous human fibroblasts and HeLa human cervical cancer cells (IC50 = 0.06 μg/ml for both).{45502} It inhibits the growth of FaDu and EVSCC17M human squamous cell carcinoma cells (IC50s = 13 and 15 μM, respectively) and of human umbilical vein endothelial cells (HUVECs; IC50 = 1 μM) in vitro.{45503,45504} Carboxyamidotriazole (20 μM) also inhibits angiogenesis in a chicken chorioallantoic membrane assay in vivo.{45504}  

 

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SKU: 28732 - 5 mg Category:

Description

An orally bioavailable, non-selective calcium channel blocker; blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 μg/ml, respectively); blocks carbachol- and A23187-stimulated calcium influx in CHO cells expressing human recombinant M5 receptors (IC50s = 935 and 359 nM, respectively); inhibits the growth of T. gondii in non-cancerous human fibroblasts and HeLa human cervical cancer cells (IC50 = 0.06 μg/ml for both); inhibits the growth of human FaDu and EVSCC17M squamous cell carcinoma cells (IC50s = 13 and 15 μM, respectively) and of HUVECs (IC50 = 1 μM); inhibits angiogenesis in a chicken chorioallantoic membrane assay in vivo at 20 μM

Formal name: 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide

Synonyms:  CAI|L-651,582|NSC 609974

Molecular weight: 424.7

CAS: 99519-84-3

Purity: ≥98%

Formulation: A solid

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