Description
An orally bioavailable, non-selective calcium channel blocker; blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 μg/ml, respectively); blocks carbachol- and A23187-stimulated calcium influx in CHO cells expressing human recombinant M5 receptors (IC50s = 935 and 359 nM, respectively); inhibits the growth of T. gondii in non-cancerous human fibroblasts and HeLa human cervical cancer cells (IC50 = 0.06 μg/ml for both); inhibits the growth of human FaDu and EVSCC17M squamous cell carcinoma cells (IC50s = 13 and 15 μM, respectively) and of HUVECs (IC50 = 1 μM); inhibits angiogenesis in a chicken chorioallantoic membrane assay in vivo at 20 μM
Formal name: 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide
Synonyms: CAI|L-651,582|NSC 609974
Molecular weight: 424.7
CAS: 99519-84-3
Purity: ≥98%
Formulation: A solid
