Description
An inhibitor of PARP1 and 2 (EC50s = 10.2 and 36.3 μM, respectively, in yeast cells expressing the human enzymes); decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells at 50 μM; reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes; reduces spinal cord expression of iNOS, IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of EAE at 60 mg/kg; decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels in a mouse model of carbon tetrachloride-induced hepatotoxicity at 10 mg/kg
Formal name:
Synonyms: NSC 11021|NSC 40943|NSC 61083
Molecular weight: 195.2
CAS: 1015-89-0
Purity: ≥98%
Formulation: A solid
