A thyroid hormone receptor agonist (EC50s = 1.81 and 4.13 nM for TRα and TRβ

Tiratricol – 500 mg

Brand:
Cayman
CAS:
51-24-1
Storage:
-20
UN-No:
Non-Hazardous - /

Tiratricol is a metabolite of 3,3′,5-triiodo-L-thyronine (Item No. 16028) and an agonist of the thyroid hormone receptors TRα and TRβ (EC50s = 1.81 and 4.13 nM, respectively, in reporter assays).{45575} In vivo, tiratricol (50 or 400 ng/g) stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in Mct8/Oatp1c1 double knockout mice.{45574} It reduces goiter induced by methimazole (Item No. 23718) in rats when administered at a dose of 25 μg per animal.{45572} Tiratricol also decreases toll-like receptor 2 (TLR2) levels and the phosphorylation of Akt and MAPK in HEK-Blue™ cells expressing human TLR2 and reduces liver tissue necrosis in a mouse model of hepatitis induced by concanavalin A (Item No. 14951).{45573}.  

 

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Description

A thyroid hormone receptor agonist (EC50s = 1.81 and 4.13 nM for TRα and TRβ, respectively, in reporter assays); stimulates cerebellar Purkinje cell dendritogenesis and cortical myelination in Mct8/Oatp1c1 double knockout mice at 50 or 400 ng/g; reduces methimazole-induced goiter in rats at 25 μg per animal; decreases TLR2 levels and the phosphorylation of Akt and MAPK in HEK-Blue™ cells expressing human TLR2; reduces liver tissue necrosis in a mouse model of concanavalin A-induced hepatitis

Formal name: 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-benzeneacetic acid

Synonyms:  3,3′,5-Triiodothyroacetic acid

Molecular weight: 621.9

CAS: 51-24-1

Purity: ≥98%

Formulation: A crystalline solid

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