An EPA metabolite and activator of BKCa channels; increases the potassium current amplitude by 15-fold in isolated rat cerebral artery VSMCs at 50 nM; has negative chronotropic effects in NRCMs (EC50 = ~1-2 nM) and prevents calcium-induced increases in NRCM spontaneous beating

17R(18S)-EpETE – 100 µg

Brand:
Cayman
CAS:
725246-18-4
Storage:
-20
UN-No:
De Minimis - 1170 / 3

17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110 | 90110.1 | 21908).{11951,9825} 17R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.{9825} It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50 = ~1-2 nM) and prevents calcium-induced increases in the spontaneous beating of NRCMs.{19905,18672}  

 

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SKU: 28630 - 100 µg Category:

Description

An EPA metabolite and activator of BKCa channels; increases the potassium current amplitude by 15-fold in isolated rat cerebral artery VSMCs at 50 nM; has negative chronotropic effects in NRCMs (EC50 = ~1-2 nM) and prevents calcium-induced increases in NRCM spontaneous beating

Formal name: 16-[(2R,3S)-3-ethyl-2-oxiranyl]-5Z,8Z,11Z,14Z-hexadecatetraenoic acid

Synonyms:  17R,18S-EEQ|17R,18S-epoxy Eicosatetraenoic Acid

Molecular weight: 318.5

CAS: 725246-18-4

Purity: ≥98%

Formulation: A solution in ethanol

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