An NSAID; selectively inhibits human COX-2 (IC50 = 0.8 μM) over COX-1 (IC50 = >100 μM) in isolated whole blood; inhibits PGE2 production in patient-derived human rheumatoid synovial cells (IC50s = 1.9-29.4 nM); reduces IL-1β-induced increases in IL-6 production by 21 and 43% in cultured chondrocytes without and with osteoarthritic lesions

Aceclofenac – 10 g

Brand:
Cayman
CAS:
89796-99-6
Storage:
-20
UN-No:
- 2811 / 6.1

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) and a derivative of diclofenac (Item Nos. 22983 | 70680).{48541} Aceclofenac inhibits the production of prostaglandin E2 (PGE2; Item No. 14010) and thromboxane B2 (TXB2; Item No. 19030) by 25 and 30%, respectively, in cell-free assays when used at concentrations of 10 and 100 µM, respectively. It selectively inhibits COX-2 in isolated whole blood (IC50s = 0.8 and >100 µM for COX-2 and COX-1, respectively) and inhibits the production of PGE2 in patient-derived human rheumatoid synovial cells (IC50s = 1.9-29.4 nM).{48541,48542} Aceclofenac reduces IL-1β-induced increases in IL-6 production by 21 and 43% in cultured chondrocytes without and with osteoarthritic lesions, respectively, when used at a concentration of 30 μM.{48541} Aceclofenac inhibits carrageenan-induced paw edema (ED50 = 3.6 mg/kg) and abscess formation (ED30 = 1.1 mg/kg) in rats.{48543} It also inhibits an increase in joint diameter in a rat model of arthritis induced by complete Freund’s adjuvant (CFA).{48544}  

 

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Description

An NSAID; selectively inhibits human COX-2 (IC50 = 0.8 μM) over COX-1 (IC50 = >100 μM) in isolated whole blood; inhibits PGE2 production in patient-derived human rheumatoid synovial cells (IC50s = 1.9-29.4 nM); reduces IL-1β-induced increases in IL-6 production by 21 and 43% in cultured chondrocytes without and with osteoarthritic lesions, respectively, at 30 μM; inhibits carrageenan-induced paw edema (ED50 = 3.6 mg/kg) and abscess formation (ED30 = 1.1 mg/kg) in rats; inhibits an increase in joint diameter in a rat model of CFA-induced arthritis

Formal name: 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, carboxymethyl ester

Synonyms: 

Molecular weight: 354.2

CAS: 89796-99-6

Purity: ≥98%

Formulation: A solid

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