A synthetic GnRH peptide agonist that binds to GnRHR (Ki = 0.3 nM in CHO cells expressing the human receptor); inhibits the growth of DU145

Triptorelin – 10 mg

Brand:
Cayman
CAS:
57773-63-4
Storage:
-20
UN-No:
Non-Hazardous - /

Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).{36464} It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).{52097} Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).{52096} It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.{52097} It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.{39555} Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.  

 

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SKU: 28613 - 10 mg Category:

Description

A synthetic GnRH peptide agonist that binds to GnRHR (Ki = 0.3 nM in CHO cells expressing the human receptor); inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively); inhibits the growth of the TNBC HCC1806 and MDA-MB-231 cancer cell lines (EC50s = 58.29 and 31.59 μM, respectively); stimulates FSH and LH release from primary rat pituitary cells at 50 nM; decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats at 1 mg/kg per day

Formal name: 6-D-tryptophan-luteinizing hormone-releasing factor (swine)

Synonyms:  ,AY 25650|[D-Trp6]-GnRH|[D-Trp6]LH-RH|BIM 21003|CL 118,53|Wy 42422|Wy 42462

Molecular weight: 1,311.50

CAS: 57773-63-4

Purity: ≥98%

Formulation: A solid

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