A nortriterpenoid; inhibits UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM

Demethylzeylasteral – 5 mg

Brand:
Cayman
CAS:
107316-88-1
Storage:
-20
UN-No:
Non-Hazardous - /

Demethylzeylasteral is a nortriterpenoid originally isolated from T. wilfordii that has diverse biological activities, including enzyme inhibitory, anti-angiogenic, antiproliferative, anti-inflammatory, and immunosuppressive properties.{45479,45480,45481,45482} Demethylzeylasteral inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM, respectively).{45480} It inhibits growth of bovine aortic endothelial cells (BAEs) and U251 human glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 μM, respectively), as well as inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma mouse allograft model when administered at a dose of 30 mg/kg per day.{45479} Demethylzeylasteral (0.12 mg/kg per day) decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-α, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice.{45481} Demethylzeylasteral (10 mg/kg per day) also increases survival of recipient rats in a model of kidney transplant.{45482}  

 

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SKU: 28595 - 5 mg Category:

Description

A nortriterpenoid; inhibits UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM, respectively); inhibits growth of BAEs and of human U251 glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 μM, respectively); inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma allograft mouse model at 30 mg/kg per day; decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-α, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice at 0.12 mg/kg per day; increases kidney transplant survival in recipient rats at 10 mg/kg per day

Formal name: (9β,13α,14β,20α)-2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid

Synonyms: 

Molecular weight: 480.6

CAS: 107316-88-1

Purity: ≥98%

Formulation: A crystalline solid

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