An orally bioavailable inhibitor of ASK1 (IC50 = 14 nM); selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1

ASK1 Inhibitor 10 – 5 mg

Brand:
Cayman
CAS:
1005775-56-3
Storage:
-20
UN-No:
Non-Hazardous - /

ASK1 inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 14 nM).{46457} It is selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF (IC50s = >10,000 nM for all). It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner.  

 

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SKU: 28512 - 5 mg Category:

Description

An orally bioavailable inhibitor of ASK1 (IC50 = 14 nM); selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF (IC50s = >10,000 nM for all); inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner

Formal name: 4-(1,1-dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-benzamide, dihydrochloride

Synonyms: 

Molecular weight: 432.4

CAS: 1005775-56-3

Purity: ≥98%

Formulation: A solid

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