A glucosylceramide synthase inhibitor (IC50 = 14 nM); reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of ALT

Genz-123346 – 100 mg

Brand:
Cayman
CAS:
491833-30-8
Storage:
-20
UN-No:
Non-Hazardous - /

Genz-123346 is a glucosylceramide synthase inhibitor (IC50 = 14 nM).{46474} It reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of alanine aminotransferase (ALT), hemoglobin A1c, and non-fasting glucose in ob/ob mice when administered at a dose of 120 mg/kg per day.{46475} Genz-123346 (125 mg/kg per day) also decreases hepatic fat mass and reduces the size and number of hepatic lipid droplets in diet-induced obese mice.  

 

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SKU: 28500 - 100 mg Category:

Description

A glucosylceramide synthase inhibitor (IC50 = 14 nM); reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of ALT, hemoglobin A1c, and non-fasting glucose in ob/ob mice at 120 mg/kg per day; decreases hepatic fat mass and reduces the size and number of hepatic lipid droplets in diet-induced obese mice at 125 mg/kg per day

Formal name: N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-nonanamide

Synonyms: 

Molecular weight: 418.6

CAS: 491833-30-8

Purity: ≥98%

Formulation: A crystalline solid

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