A triterpene glycoside; inhibits glucose-induced phosphorylation of serine 70 on S6K1 and serine 2448 on mTOR

Gymnemic Acid I – 1 mg

Brand:
Cayman
CAS:
122168-40-5
Storage:
-20
UN-No:
Non-Hazardous - /

Gymnemic acid I is a triterpene glycoside that has been found in G. sylvestre and has antihyperglycemic activities.{45515,45513} It inhibits glucose-induced phosphorylation of serine 70 on S6 kinase (S6K1) and serine 2448 on mTOR, caspase-3 activity, and apoptosis, as well as increases autophagy in MIN-6 pancreatic β cells when used at a concentration of 5 µg/ml.{45515} Gymnemic acid I has been used as a reference compound to compare the potency of plant-derived sweet taste inhibitors.{45513}  

 

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SKU: 28495 - 1 mg Category:

Description

A triterpene glycoside; inhibits glucose-induced phosphorylation of serine 70 on S6K1 and serine 2448 on mTOR, caspase-3 activity, and apoptosis, as well as increases authophagy in MIN-6 pancreatic β cells at 5 µg/ml; has been used as a reference compound to compare the potency of plant-derived sweet taste inhibitors.

Formal name: (3β,4α,16β,21β,22α)-28-(acetyloxy)-16,22,23-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl-β-D-glucopyranosiduronic acid

Synonyms:  (+)-Gymnemic Acid I

Molecular weight: 807

CAS: 122168-40-5

Purity: ≥98%

Formulation: A crystalline solid

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