An irreversible inhibitor of the NLRP3 inflammasome; inhibits activation of caspase-1 and release of IL-1β and LDH induced by ATP or nigericin in LPS-primed BMDMs at 10 µM; reduces ATP-induced pyroptosis in LPS-primed THP-1 cells by 33.6% at 10 µM; prevents increases in IL-1β protein levels induced by DNBS in the colon in a rat model of colitis; reduces the severity of pancreatic lesions and serum levels of IL-1β

INF39 – 5 mg

Brand:
Cayman
CAS:
866028-26-4
Storage:
-20
UN-No:
Non-Hazardous - /

INF39 is an irreversible inhibitor of the NLRP3 inflammasome.{46402} INF39 (10 µM) inhibits activation of caspase-1 and the release of IL-1β and lactate dehydrogenase (LDH) induced by ATP (Item No. 14498) or nigericin (Item No. 11437) in LPS-primed bone marrow-derived macrophages (BMDMs). It reduces ATP-induced pyroptosis in LPS-primed THP-1 cells by 33.6% when used at a concentration of 10 µM. INF39 (12.5, 25, and 50 mg/kg) prevents increases in IL-1β protein levels induced by dinitrobenzene sulfonic acid (DNBS) in the colon in a rat model of colitis. It reduces the severity of pancreatic lesions and serum levels of IL-1β, TNF-α, and IL-6 during caerulein- and LPS-induced pancreatitis in mice when administered at doses of 25 and 50 mg/kg.{46403}  

 

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SKU: 28476 - 5 mg Category:

Description

An irreversible inhibitor of the NLRP3 inflammasome; inhibits activation of caspase-1 and release of IL-1β and LDH induced by ATP or nigericin in LPS-primed BMDMs at 10 µM; reduces ATP-induced pyroptosis in LPS-primed THP-1 cells by 33.6% at 10 µM; prevents increases in IL-1β protein levels induced by DNBS in the colon in a rat model of colitis; reduces the severity of pancreatic lesions and serum levels of IL-1β, TNF-α, and IL-6 during caerulein- and LPS-induced pancreatitis in mice at 25 and 50 mg/kg

Formal name: 2-chloro-α-methylene-benzenepropanoic acid, ethyl ester

Synonyms: 

Molecular weight: 224.7

CAS: 866028-26-4

Purity: ≥98%

Formulation: An oil

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