Description
A PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively); induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines at 5 µg/ml; reduces angiogenesis in a chick chorioallantoic membrane assay at 500-5,000 µg/ml; inhibits growth in a panel of nine human cancer cell lines (GI50s = 30-64 µM); reduces tumor growth in a GBC-SD mouse xenograft model at 28 mg/kg
Formal name: (3aR,4S,7R,7aS)-rel-hexahydro-4,7-epoxyisobenzofuran-1,3-dione
Synonyms: Demethylcantharidin|NCTD|NSC 59023
Molecular weight: 168.1
CAS: 29745-04-8
Purity: ≥95%
Formulation: A crystalline solid
