An adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for human and rhesus monkey receptors

Tozadenant – 50 mg

Brand:
Cayman
CAS:
870070-55-6
Storage:
-20
UN-No:
Non-Hazardous - /

Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively).{47787} It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330) when administered at a dose of 30 mg/kg.{47788} Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson’s disease.{47789}  

 

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Description

An adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for human and rhesus monkey receptors, respectively); increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson’s disease induced by 6-OHDA at 30 mg/kg; reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson’s disease at 150 mg/kg

Formal name: 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide

Synonyms: 

Molecular weight: 406.5

CAS: 870070-55-6

Purity: ≥98%

Formulation: A crystalline solid

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