A dual agonist of TLR7 and TLR8 (EC50s = 50 and 55 nM

TLR7/8 Agonist 1 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1620278-72-9
Storage:
-20
UN-No:
Non-Hazardous - /

TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8 (EC50s = 50 and 55 nM, respectively, in cell-based assays).{47662} It increases the levels of TNF-α, IFN-γ, IL-12p40, and chemokine (C-C motif) ligand 4 (CCL4) in human peripheral blood mononuclear cells (PBMCs) in a biphasic manner. TLR7/8 agonist 1 (25 nmol, s.c.) increases serum levels of IL-12p40 and chemokine (C-X-C motif) ligand 10 (CXCL10), as well as the number of dendritic cells per injection-site proximal lymph node, in mice.{47663} It has been conjugated to various fluorophores as TLR7 probes and to polymer particles for the modulation of TLR7/8 agonist 1 adjuvant activity.{47664,47663}  

 

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SKU: 28451 - 5 mg Category:

Description

A dual agonist of TLR7 and TLR8 (EC50s = 50 and 55 nM, respectively, in cell-based assays); increases the levels of TNF-α, IFN-γ, IL-12p40, and CCL4 in PBMCs in a biphasic manner; increases serum levels of IL-12p40 and CXCL10, as well as the number of dendritic cells per injection-site proximal lymph node, in mice at 25 nmol; has been conjugated to various fluorophores as TLR7 probes and to polymer particles for the modulation of adjuvant activity

Formal name: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine, dihydrochloride

Synonyms: 

Molecular weight: 432.4

CAS: 1620278-72-9

Purity: ≥98%

Formulation: A solid

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