Description
A TLR7 agonist (LEC = 0.4 μM in a cell-based reporter assay); selective for TLR7 over TLR8 (LEC = >100 μM); increases IFN-α levels and the ISG response, increasing the expression of Oas1b, Isg15, and Mx1, in mouse liver and plasma at 0.3-10 mg/kg; increases plasma levels of IFN-α, CCL2, IL-6, IL-1Ra, G-CSF, and IL-10 in cynomolgus monkeys at 10 mg/kg; reduces serum and liver viral load in the HDI-HBV mouse model at 0.3-5 mg/kg
Formal name: 4-[(5-methyl-3-isoxazolyl)methoxy]-5-(2-pyridinylmethyl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine
Synonyms:
Molecular weight: 336.4
CAS: 1642857-69-9
Purity: ≥98%
Formulation: A crystalline solid
