An immunomodulator; reduces splenic counts of Ly6ChiCD115+ inflammatory monocytes and CD11b+CD11c+ dendritic cells in a mouse model of EAE; reduces hepatic fibrosis and accumulation of inflammatory monocytes and neutrophils in the N-IF mouse model of liver fibrosis at 25 mg/kg per day; delays disease onset and decreases insulitis in NOD mice; reduces skin thickness

Paquinimod – 1 mg

Brand:
Cayman
CAS:
248282-01-1
Storage:
-20
UN-No:
Non-Hazardous - /

Paquinimod is an immunomodulator.{52191,52192,52193,52194} In vivo, paquinimod reduces splenic counts of Ly6ChiCD115+ inflammatory monocytes and CD11b+CD11c+ dendritic cells in a mouse model of experimental autoimmune encephalomyelitis (EAE).{52191} Paquinimod (25 mg/kg per day) reduces hepatic fibrosis and accumulation of inflammatory monocytes and neutrophils in the N-IF mouse model of liver fibrosis.{52192} It delays disease onset and decreases insulitis in non-obese diabetic (NOD) mice.{52193} Paquinimod (5 and 25 mg/kg) reduces skin thickness, the number of myofibroblasts, and autoantibody production in the tight skin 1 mouse model of systemic sclerosis.{52194}  

 

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SKU: 28443 - 1 mg Category:

Description

An immunomodulator; reduces splenic counts of Ly6ChiCD115+ inflammatory monocytes and CD11b+CD11c+ dendritic cells in a mouse model of EAE; reduces hepatic fibrosis and accumulation of inflammatory monocytes and neutrophils in the N-IF mouse model of liver fibrosis at 25 mg/kg per day; delays disease onset and decreases insulitis in NOD mice; reduces skin thickness, the number of myofibroblasts, and autoantibody production in the tight skin 1 mouse model of systemic sclerosis at 5 and 25 mg/kg

Formal name: N,5-diethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide

Synonyms:  ABR-25757

Molecular weight: 350.4

CAS: 248282-01-1

Purity: ≥98%

Formulation: A solid

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