A selective adenosine A1 receptor agonist (Kis = 3.1 and 1

GR79236 – 10 mg

Brand:
Cayman
CAS:
124555-18-6
Storage:
-20
UN-No:
- /

GR79236 is a selective agonist of adenosine A1 receptors (Kis = 3.1 and 1,300 nM for adenosine A1 and A2 receptors, respectively, in rat brain).{47666} GR79236 inhibits cAMP accumulation induced by isoprenaline (isoproterenol; Item No. 15592) in DDT1MF-2 hamster smooth muscle cells (IC50 = 2.6 nM) but only decreases contractility in isolated guinea pig atria with an EC50 value of 1,500 nM. It also inhibits lipolysis induced by norepinephrine (Item No. 16673) in rat adipocytes (EC50 = 0.83 nM).{47667} GR79236 decreases locomotor activity and inhibits DMCM-induced seizures in mice (ED50s = 0.13 and 0.3 mg/kg, respectively).{47666} It also decreases mean blood pressure by 74% in anesthetized rats when administered at a dose of 0.1 mg/kg.  

 

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SKU: 28430 - 10 mg Category:

Description

A selective adenosine A1 receptor agonist (Kis = 3.1 and 1,300 nM for adenosine A1 and A2 receptors, respectively, in rat brain; inhibits isoprenaline-induced cAMP accumulation in DDT1MF-2 hamster smooth muscle cells (IC50 = 2.6 nM) but only decreases contractility in isolated guinea pig atria with an EC50 value of 1,500 nM; inhibits norepinephrine-induced lipolysis in rat adipocytes (EC50 = 0.83 nM); decreases locomotor activity and inhibits DMCM-induced seizures in mice (ED50s = 0.13 and 0.3 mg/kg, respectively); decreases blood pressure by 74% in anesthetized rats at 0.1 mg/kg

Formal name: N-[(1S,2S)-2-hydroxycyclopentyl]-adenosine

Synonyms: 

Molecular weight: 351.4

CAS: 124555-18-6

Purity: ≥98%

Formulation: A solid

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