A tryptanthrin derivative with diverse biological activities; inhibits human recombinant IDO1 (IC50 = 0.103 μM) and its enzyme activity in HEK293 cells expressing human IDO1 (IC50 = 0.18 μM); inhibits growth of U251

8-Nitrotryptanthrin – 1 mg

Brand:
Cayman
CAS:
77603-42-0
Storage:
-20
UN-No:
Non-Hazardous - /

8-Nitrotryptanthrin is a derivative of tryptanthrin (Item No. 17913) with diverse biological activities.{46490,46491,46492,46493,50117} It inhibits human recombinant indoleamine 2,3-dioxygenase 1 (IDO1; IC50 = 0.103 μM) and its enzyme activity in HEK293 cells expressing human IDO1 (IC50 = 0.18 μM).{46490} 8-Nitrotryptanthrin inhibits the growth of U251 glioblastoma, H522 lung, M14 melanoma, DU145 prostate, and A498 renal cancer cells (GI50s = 4.5, 4.8, 15, 8, and 2 μM, respectively).{46491} It is active against M. tuberculosis, methicillin resistant S. aureus (MRSA), and M. furfur (MICs = 0.032, 0.5, and 5 μg/ml, respectively).{46492,46493} 8-Nitrotyrptanthrin is also active against T. brucei (EC50 = 0.24 μg/ml).{50117}  

 

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SKU: 28429 - 1 mg Category:

Description

A tryptanthrin derivative with diverse biological activities; inhibits human recombinant IDO1 (IC50 = 0.103 μM) and its enzyme activity in HEK293 cells expressing human IDO1 (IC50 = 0.18 μM); inhibits growth of U251, H522, M14, DU145 and A498 cancer cells (GI50s = 4.5, 4.8, 15, 8, and 2 μM, respectively); active against M. tuberculosis, MRSA, and M. furfur (MICs = 0.032, 0.5, and 5 μg/ml, respectively); active against T. brucei (EC50 = 0.24 μg/ml)

Formal name: 8-nitro-indolo[2,1-b]quinazoline-6,12-dione

Synonyms:  GNF-PF-3777

Molecular weight: 293.2

CAS: 77603-42-0

Purity: ≥98%

Formulation: A crystalline solid

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