Description
An irreversible MPO inhibitor (Ki = 316.23 nM in a cell-free assay); selective for MPO over TPO in a resorufin formation assay, as well as a panel of more than 50 enzymes, receptors, transporters, and ion channels at 100 µM; reduces necrotic core area in atherosclerotic lesions by 37% in the aortic root of Ldlr-/- mice fed a Western diet at 15 mg/kg twice per day for 14 weeks
Formal name: 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide
Synonyms:
Molecular weight: 325.8
CAS: 1435467-37-0
Purity: ≥95%
Formulation: A crystalline solid
