An iridoid glycoside; stimulates GLP-1 secretion by NCI H716 human enteroendocrine colorectal cancer cells at 1 μM; inhibits dexamethasone-

Loganic Acid – 50 mg

Brand:
Cayman
CAS:
22255-40-9
Storage:
-20
UN-No:
Non-Hazardous - /

Loganic acid is an iridoid glycoside that has been found in C. mas and has diverse biological activities, including antidiabetic, antiadipogenic, anti-atherosclerotic, and anti-inflammatory properties.{46430,46431,46432,46433} Loganic acid (1 μM) stimulates glucagon-like peptide-1 (GLP-1) secretion by NCI H716 human enteroendocrine colorectal cancer cells.{46431} It inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes when used at a concentration of 10 μg/ml.{46432} Loganic acid (20 mg/kg per day) decreases the plasma atherogenic index, a ratio of triglyceride to HDL cholesterol, and the cardiac risk ratio, a ratio of total cholesterol to HDL cholesterol, in a rabbit model of atherosclerosis induced by a cholesterol-rich diet.{46433} It also decreases IL-6, TNF-α, and oxidized LDL (oxLDL) plasma levels in the same model.  

 

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SKU: 28402 - 50 mg Category:

Description

An iridoid glycoside; stimulates GLP-1 secretion by NCI H716 human enteroendocrine colorectal cancer cells at 1 μM; inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes at 10 μg/ml; decreases the plasma atherogenic index and cardiac risk ratio, as well as plasma levels of IL-6, TNF-α, and oxLDL in a cholesterol-rich diet-induced rabbit model of atherosclerosis

Formal name: (1S,4aS,6S,7R,7aS)-1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-cyclopenta[c]pyran-4-carboxylic acid

Synonyms:  Loganate|Loganin Acid

Molecular weight: 376.4

CAS: 22255-40-9

Purity: ≥98%

Formulation: A solid

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