Description
An inhibitor of galectin-3; binds selectively to galectin-3 (Kd = 0.036 µM) over galectin-1 and galectin-7 (Kds = 2.2 and 32 µM, respectively) at 4°C, but it is not selective over galectin-1 in a fluorescence anisotropy assay (Kds = 0.014 and 0.01 µM for galectin-3 and -1, respectively); selective for galectin-3 and galectin-1 over galectin-2, -4N, -4C, -7, -8N, -9N, and -9C (Kds = >5, 0.17, 0.14, 1.9, 86, 0.68, and 0.12 µM, respectively) in a fluorescence anisotropy assay; decreases amitriptyline-induced galectin-3 accumulation in MCF-7 cells; reduces β-catenin activation in the lung and lung fibrosis in a bleomycin-induced mouse model of idiopathic pulmonary fibrosis at 10 µg/animal via lung instillation
Formal name: 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-β-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-β-D-galactopyranoside
Synonyms:
Molecular weight: 648.6
CAS: 1450824-22-2
Purity: ≥98%
Formulation: A crystalline solid
