Description
An inhibitor of PDE3 (IC50 = 0.35 μM for human cardiac enzyme); selective for PDE3 over PDE1 and PDE2 (IC50s = 150 and 100 μM, respectively); induces relaxation of precontracted isolated rabbit renal and carotid arterial rings (IC50s = 40 and 103 nM, respectively); reduces infarct size and improves cardiac function in a rat model of myocardial ischemia-reperfusion injury at 0.6 mg/kg twice per day; reduces cortical and striatal damage, as well as reduces injured cerebral tissue nitrotyrosine formation, apoptosis, and levels of iNOS, IL-1β, and ICAM-1 in a rat model of cerebral ischemia-reperfusion injury at 0.2 mg/kg; inhibits neutrophil infiltration into lung and inhibits increases in serum levels of TNF-α and IL-6 in a rat model of LPS-induced lung inflammation at 0.2 mg/kg
Formal name: 1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile, monohydrochloride
Synonyms: Loprinone
Molecular weight: 286.7
CAS: 119615-63-3
Purity: ≥98%
Formulation: A crystalline solid
