A peripherally selective androgen receptor antagonist; binds to AR and inhibits AR-regulated transcription in a reporter cell line in vitro; inhibits androgen-regulated lipid synthesis in primary human sebocytes; inhibits inflammatory cytokine production from primary human sebocytes and scalp dermal papilla cells; inhibits testosterone propionate-induced flank organ enlargement in Syrian golden hamsters by 84% when administered topically at 400 μg/animal

Cortexolone 17α-propionate – 10 mg

Brand:
Cayman
CAS:
19608-29-8
Storage:
-20
UN-No:
Non-Hazardous - /

Cortexolone 17α-propionate is a peripherally selective androgen receptor antagonist.{45540} Cortexolone 17α-propionate binds to the androgen receptor (AR) and inhibits AR-regulated transcription in a reporter assay.{45539} It also inhibits androgen-regulated lipid synthesis in primary human sebocytes. Cortexolone 17α-propionate inhibits inflammatory cytokine production from primary human sebocytes and scalp dermal papilla cells.{45539,45538} It inhibits testosterone propionate-induced flank organ enlargement in Syrian golden hamsters by 84% when administered topically at a dose of 400 μg/animal.  

 

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Description

A peripherally selective androgen receptor antagonist; binds to AR and inhibits AR-regulated transcription in a reporter cell line in vitro; inhibits androgen-regulated lipid synthesis in primary human sebocytes; inhibits inflammatory cytokine production from primary human sebocytes and scalp dermal papilla cells; inhibits testosterone propionate-induced flank organ enlargement in Syrian golden hamsters by 84% when administered topically at 400 μg/animal

Formal name: 21-hydroxy-17-(1-oxopropoxy)-pregn-4-ene-3,20-dione

Synonyms:  CB-03-01

Molecular weight: 402.5

CAS: 19608-29-8

Purity: ≥98%

Formulation: A solid

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