An 8-hydroxyquinoline; active against the bacteria E. coli

Nitroxoline – 5 g

Brand:
Cayman
CAS:
4008-48-4
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Nitroxoline is an 8-hydroxyquinoline that has diverse biological activities, including antibacterial, antiproliferative, and bromodomain interaction-inhibiting properties.{45442,45443,45444,45445} Nitroxoline is active against the bacteria E. coli, S. aureus, E. faecalis, K. pneumoniae, and P. mirabilis in vitro (MIC90s = 4, 4, 8, 8, and 8 mg/L, respectively).{45442} It also inhibits biofilm formation of certain strains of multidrug-resistant (MDR) A. baumannii and P. aeruginosa, as well as methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE) with minimum biofilm eradication concentration (MBEC) values of 46.9, 1,500, 188, and 125 μM, respectively.{45443} Nitroxoline inhibits the growth of human U87 and U251 glioma, A549 lung, and PC3 prostate cancer cells (IC50s = 50, 6, 38, and 23 μg/ml, respectively).{45444} In vivo, it reduces tumor growth in a PTEN- and KRAS-driven glioma mouse model when administered at a dose of 80 mg/kg per day. Nitroxoline also inhibits the interaction between the first bromodomain of bromodomain-containing protein 4 (BRD4) with acetylated histone H4 with an IC50 value of 0.98 μM.{45445}  

 

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SKU: 28391 - 5 g Category:

Description

An 8-hydroxyquinoline; active against the bacteria E. coli, S. aureus, E. faecalis, K. pneumoniae, and P. mirabilis in vitro (MIC90s = 4, 4, 8, 8, and 8 mg/L, respectively); inhibits biofilm formation of certain strains of MDR A. baumannii and P. aeruginosa, as well as MRSA and MRSE (MBECs = 46.9, 1,500, 188, and 125 μM, respectively); inhibits the growth of human U87 and U251 glioma, A549 lung, and PC3 prostate cancer cells (IC50s = 50, 6, 38, and 23 μg/ml, respectively); reduces tumor growth in a PTEN- and KRAS-driven glioma mouse model at 80 mg/kg per day; inhibits the interaction between the first bromodomain of BRD4 with acetylated histone H4 (IC50 = 0.98 μM)

Formal name: 5-nitro-8-quinolinol

Synonyms:  5-Nitro-8-hydroxyquinoline|8-Hydroxy-5-nitroquinoline

Molecular weight: 190.2

CAS: 4008-48-4

Purity: ≥95%

Formulation: A crystalline solid

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