A histamine H1 receptor antagonist (IC50 = 180 nM); selective for the histamine H1 receptor in a panel of 30 receptors in vitro at 100 µM; prevents microvascular extravasation (ED50 = 185 µg/kg

Bilastine – 250 mg

Brand:
Cayman
CAS:
202189-78-4
Storage:
-20
UN-No:
Non-Hazardous - /

Bilastine is a histamine H1 receptor antagonist (IC50 = 180 nM).{42911} It is selective for the histamine H1 receptor in a panel of 30 receptors in vitro at 100 µM. Bilastine prevents microvascular extravasation (ED50 = 185 µg/kg, i.v.), bronchospasm (ED50 = 4.6 µg/kg, i.v.), and systemic anaphylaxis (ED50 = 0.2 µg/kg, p.o.) induced by subcutaneous histamine in guinea pigs.{42912} It prevents anaphylaxis induced by subcutaneous administration of ovalbumin or dinitrophenylated human albumin (DNP) in sensitized rats when administered at doses of 7.6 and 6.0 mg/kg, respectively. Formulations containing bilastine have been used in the treatment of urticaria and allergic rhinitis.  

 

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SKU: 28375 - 250 mg Category:

Description

A histamine H1 receptor antagonist (IC50 = 180 nM); selective for the histamine H1 receptor in a panel of 30 receptors in vitro at 100 µM; prevents microvascular extravasation (ED50 = 185 µg/kg, i.v.), bronchospasm (ED50 = 4.6 µg/kg, i.v.), and systemic anaphylaxis (ED50 = 0.2 µg/kg, p.o.) induced by subcutaneous histamine in guinea pigs; prevents anaphylaxis induced by subcutaneous administration of ovalbumin or DNP in sensitized rats at 7.6 and 6.0 mg/kg, respectively

Formal name: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-α,α-dimethyl-benzeneacetic acid

Synonyms:  F-96221-BM1

Molecular weight: 463.6

CAS: 202189-78-4

Purity: ≥98%

Formulation: A crystalline solid

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