A prodrug form of adefovir; inhibits HBV DNA synthesis in HepG2 2.2.15 cells infected with HBV (EC50 = 0.517 μM); cytotoxic to HepG2 2.2.15 cells (CC50 = 540 μM); inhibits HBV replication in the liver of HBV transgenic mice (ED50 = 0.2 μmol/kg per day)

Adefovir dipivoxil – 25 mg

Brand:
Cayman
CAS:
142340-99-6
Storage:
-20
UN-No:
Non-Hazardous - /

Adefovir dipivoxil is a prodrug form of the antiviral nucleoside analog adefovir (Item No. 18650).{45446} Adefovir dipivoxil inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 2.2.15 cells infected with HBV (EC50 = 0.517 μM).{45447} It is cytotoxic to HepG2 2.2.15 cells with a 50% cytotoxicity concentration (CC50) value of 540 μM. Adefovir dipivoxil inhibits HBV replication in the liver of HBV transgenic mice (ED50 = 0.2 μmol/kg per day).{45448} Formulations containing adefovir dipivoxil have been used in the treatment of chronic HBV infection.  

 

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SKU: 28373 - 25 mg Category:

Description

A prodrug form of adefovir; inhibits HBV DNA synthesis in HepG2 2.2.15 cells infected with HBV (EC50 = 0.517 μM); cytotoxic to HepG2 2.2.15 cells (CC50 = 540 μM); inhibits HBV replication in the liver of HBV transgenic mice (ED50 = 0.2 μmol/kg per day),,

Formal name: 2,2-dimethyl-propanoic acid, 1,1′-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester

Synonyms:  GS 0840

Molecular weight: 501.5

CAS: 142340-99-6

Purity: ≥98%

Formulation: A crystalline solid

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