Firocoxib is a selective inhibitor of COX-2 (IC50s = 0.13 and 7.5 µM for COX-2 and COX-1

Firocoxib – 50 mg

Brand:
Cayman
CAS:
189954-96-9
Storage:
-20
UN-No:
Non-Hazardous - /

Firocoxib is a selective inhibitor of COX-2 (IC50s = 0.13 and 7.5 µM for COX-2 and COX-1, respectively, in isolated cat blood).{50228} It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated dog, horse, and cat whole blood ex vivo.{50230,50231,50228} Firocoxib decreases lameness, induces analgesia, and improves range of motion in dogs and horses with osteoarthritis when administered at doses of 5 and 0.1 mg/kg per day, respectively.{50232,50233} Formulations containing firocoxib have been used in dogs and horses with osteoarthritis.  

 

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SKU: 28286 - 50 mg Category:

Description

Firocoxib is a selective inhibitor of COX-2 (IC50s = 0.13 and 7.5 µM for COX-2 and COX-1, respectively, in isolated cat blood); inhibits LPS-induced production of PGE2 in isolated dog, horse, and cat whole blood; decreases lameness, induces analgesia, and improves range of motion in dog and horses with osteoarthritis at 5 and 0.1 mg/kg per day, respectively

Formal name: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone

Synonyms:  ML-1785713

Molecular weight: 336.4

CAS: 189954-96-9

Purity: ≥98%

Formulation: A crystalline solid

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