A nootropic agent; inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and 5-HT reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM); increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson's disease; reduces rotenone-induced depletion of dopamine and GSH

Meclofenoxate (hydrochloride) – 25 g

Brand:
Cayman
CAS:
3685-84-5
Storage:
-20
UN-No:
Non-Hazardous - /

Meclofenoxate is a nootropic agent.{51141} It inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and serotonin (5-HT) reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM). Meclofenoxate increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease.{51142} It reduces rotenone-induced depletion of dopamine and glutathione (GSH), lipid peroxidation, production of nitric oxide (NO), and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease when administered at a dose of 100 mg/kg.{51143} Meclofenoxate (100 mg/kg) increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats.{51144} It also reduces neuronal lipofuscin pigment, a marker of aging, in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice.{51145} Formulations containing meclofenoxate have been used in the treatment of senile dementia.  

 

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SKU: 28283 - 25 g Category:

Description

A nootropic agent; inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and 5-HT reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM); increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease; reduces rotenone-induced depletion of dopamine and GSH, lipid peroxidation, production of NO, and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease at 100 mg/kg; increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats at 100 mg/kg; reduces neuronal lipofuscin pigment in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice

Formal name: 2-(4-chlorophenoxy)-acetic acid, 2-(dimethylamino)ethyl ester, monohydrochloride

Synonyms:  Dimethylaminoethyl 4-chlorophenoxyacetate|Methocynal

Molecular weight: 294.2

CAS: 3685-84-5

Purity: ≥98%

Formulation: A solid

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